Fig. 1

Time course of mean [20, 21] and median [17] heart rate changes from baseline, and mean [16, 20, 23] and median [17] blood pressure changes [17, 20, 23] from baseline in combretastatin A4-phosphate (CA4P) studies reporting such data. CA4P infusion occurred at time 0. Means of published data points are shown. Standard error of the mean is indicated with error bars