Figure 1From: Dasatinib (BMS-35482) potentiates the activity of gemcitabine and docetaxel in uterine leiomyosarcoma cell lines The pSRC/tSRC ratio after treatment with single-agent dasatinib. In SK-UT-1, activation of the SRC kinase (pSRC/tSRC) pathway was inhibited by dasatinib at 30 nm (84%), 100 nm (92%) and 500 nm (98%). In SK-UT-1B, the SRC kinase activity was reduced in the presence of dasatinib at 30 nm (91%), 100 nm (91%) and 500 nm (95%).Back to article page