Figure 5
The inhibitory effect of gemcitabine and docetaxel at different concentrations combined with dasatinib IC 25 and the coefficient of drug interaction (CDI). CDI < 1 indicates synergism, CDI < 0.7 significant synergism, CDI = 1 additivity and CD > 1 antagonism. In SK-UT-1, the combination of gemcitabine-dasatinib, at all concentrations analyzed demonstrated decreased cell viability (A) and yielded a CDI <1 indicating synergistic effects (average CDI = 0.72) (B); the combination of docetaxel-dasatinib demonstrated decreased cell viability (C) and synergistic effects (average CDI = 0.80) (D). In SK-UT-1B the combination of gemcitabine-dasatinib, at all concentrations analyzed demonstrated decreased cell viability (E) and yielded a CDI <1 indicating synergistic effects (average CDI = 0.83) (F); the combination of docetaxel-dasatinib demonstrated decreased cell viability (G) and synergistic effects (CDI = 0.93) (H).