Cell Line
|
Drugs
|
IC
50
|
CDI
|
---|
SK-UT-1
| | | |
|
Gemcitabine
|
4.02 (SD ± 1.0)
| |
|
Docetaxel
|
4.30 (SD ± 0.5)
| |
|
Gemcitabine:Dasatinib IC25
|
2.35 (SD ± 1.4)
|
0.72
|
|
Docetaxel:Dasatinib IC25
|
1.15 (SD ± 0.07)
|
0.80
|
SK-UT-1B
| | | |
|
Gemcitabine
|
2.97 (SD ± 0.5)
| |
|
Docetaxel
|
0.94 (SD ± 0.6)
| |
|
Gemcitabine:Dasatinib IC25
|
0.85 (SD ± 0.6)
|
0.83
|
|
Docetaxel:Dasatinib IC25
|
0.52 (SD ± 0.4)
|
0.93
|
- SD = standard deviation.
- IC50 = 50% of maximal inhibitory concentration.
- IC25 = 25% of maximal inhibitory concentration.
- CDI = Coefficient of drug interaction. Calculation utilize when one drug does not achieve an IC50.
- CDI scale = CDI < 1 indicates synergism between dasatinib and cytotoxic agents, whereas CDI < 0.7 indicates significant synergism.