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Table 1 IC 50 of each cytotoxic agent alone and in combination with dasatinib (IC 25 ) and coefficient of drug interaction (CDI)

From: Dasatinib (BMS-35482) potentiates the activity of gemcitabine and docetaxel in uterine leiomyosarcoma cell lines

Cell Line Drugs IC 50 CDI
SK-UT-1    
  Gemcitabine 4.02 (SD ± 1.0)  
  Docetaxel 4.30 (SD ± 0.5)  
  Gemcitabine:Dasatinib IC25 2.35 (SD ± 1.4) 0.72
  Docetaxel:Dasatinib IC25 1.15 (SD ± 0.07) 0.80
SK-UT-1B    
  Gemcitabine 2.97 (SD ± 0.5)  
  Docetaxel 0.94 (SD ± 0.6)  
  Gemcitabine:Dasatinib IC25 0.85 (SD ± 0.6) 0.83
  Docetaxel:Dasatinib IC25 0.52 (SD ± 0.4) 0.93
  1. SD = standard deviation.
  2. IC50 = 50% of maximal inhibitory concentration.
  3. IC25 = 25% of maximal inhibitory concentration.
  4. CDI = Coefficient of drug interaction. Calculation utilize when one drug does not achieve an IC50.
  5. CDI scale = CDI < 1 indicates synergism between dasatinib and cytotoxic agents, whereas CDI < 0.7 indicates significant synergism.
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Gynecologic Oncology Research and Practice

ISSN: 2053-6844

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