Targeted agents
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VEGF-dependent angiogenesis inhibition
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Cediranib (AZD2171)/US20070135462 (AstraZeneca)
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Oral VEGFR-1,-2,-3 tyrosine kinase inhibitor
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Nintedanib (BIBF1120)/US20140018405 (Boehringer Ingelheim)
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Oral VEGFR, PDGFR, FGFR tyrosine kinase inhibitor
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PARP inhibitors
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Olaparib (AZD2281)/US2010098763 (AstraZeneca)
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Oral Poly (ADP-ribose) polymerase-1,-2 inhibitor
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Rucaparib (CO-338)/US8765751 (Clovis Oncology)
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Oral Poly (ADP-ribose) polymerase-1,-2 inhibitor
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Niraparib (MK-4827)/US20120035244 (Merck)
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Oral Poly (ADP-ribose) polymerase-1,-2 inhibitor
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MEK inhibitors
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Selumetinib (AZD6244)/US8193229 (Array BioPharma/AstraZeneca)
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Oral inhibitor of MEK-1,-2
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Binimetinib (MEK162)/US20130273061 (Array BioPharma/Novartis)
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Oral inhibitor of MEK-1,-2
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Cytotoxic agents
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Etirinotecan pegol (NKTR-102)/US20090074704 (Nektar)
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Inhibits Topoisomerase I (IV)
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Paclitaxel poliglumex (CT2103)/US20070167349 (CTI BioPharma)
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Mitotic inhibitor (IV)
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Lurbinectedin (PM1183)/US20130266666 (PharmaMar)
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Marine-derived DNA minor groove binder (IV)
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Therapeutic vaccines
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Catumaxomab/US20120095192 (Trion Pharma)
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Oral tri-functional antibody binds EpCAM, CD3, and Fc receptor
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