Table 2 Subtypes of adenocarcinomas of Mullerian origin

Precursor lesion

Tubal intraepithelial carcinoma

Atypical serous borderline tumor

Metaplasia of transitional cells or metastasis from GI primary tumor*

Atypical Endometriosis

Atypical Endometriosis

Histologic features

Positive: p16, CK7, WT-1, PAX-8, ER, CA125, E-cadherin (in most cases), p53

Positive: PAX8, ER, WT-1,

Positive: CK7, PAX-8 (40%), p53 (30%)

Positive: CK7, PAX-8, HNF-1β

Positive: CK7, ER, PR, PAX-8

Negative: Her-2, calretinin, CK20

Negative: p53 and p16 (negative, scattered or patchy)

Negative: WT-1, ER, PR and p16

Negative: CK20, ER, WT-1, p53 and p16 (negative, weak, focal or patchy)

Negative: WT-1, p16, CK 20, p53

Molecular aberrations

TP53 mutations

BRAF, KRAS, NRAS mutations

KRAS mutation

PTEN loss

PTEN loss

BRCA1/2 mutations

HER2 amplification

PIK3CA mutation

PIK3CA mutation

Chromosomal instability

ARID1A mutation

ARID1A mutation

Risk factors

Inherited BRCA1/2 mutation

Endometriosis

Endometriosis

Lynch syndrome