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Table 2 Subtypes of adenocarcinomas of Mullerian origin

From: Adenocarcinoma of Mullerian origin: review of pathogenesis, molecular biology, and emerging treatment paradigms

  High-grade serous Low-grade serous Mucinous Clear cell Endometrioid
Precursor lesion Tubal intraepithelial carcinoma Atypical serous borderline tumor Metaplasia of transitional cells or metastasis from GI primary tumor* Atypical Endometriosis Atypical Endometriosis
Histologic features Positive: p16, CK7, WT-1, PAX-8, ER, CA125, E-cadherin (in most cases), p53 Positive: PAX8, ER, WT-1, Positive: CK7, PAX-8 (40%), p53 (30%) Positive: CK7, PAX-8, HNF-1β Positive: CK7, ER, PR, PAX-8
Negative: Her-2, calretinin, CK20 Negative: p53 and p16 (negative, scattered or patchy) Negative: WT-1, ER, PR and p16 Negative: CK20, ER, WT-1, p53 and p16 (negative, weak, focal or patchy) Negative: WT-1, p16, CK 20, p53
Molecular aberrations TP53 mutations BRAF, KRAS, NRAS mutations KRAS mutation PTEN loss PTEN loss
BRCA1/2 mutations HER2 amplification PIK3CA mutation PIK3CA mutation
Chromosomal instability ARID1A mutation ARID1A mutation
Risk factors Inherited BRCA1/2 mutation    Endometriosis Endometriosis
Lynch syndrome
  1. *Origin of Mullerian mucinous tumors is not definitively known.