TY - JOUR AU - Castro, Michael P. AU - Whitcomb, Bradford P. AU - Zajchowski, Deborah A. AU - Coleman, Robert L. PY - 2015 DA - 2015/08/28 TI - Successful use of next generation genomic sequencing (NGS)-directed therapy of clear cell carcinoma of the ovary (CCCO) with trametinib and metformin in a patient with chemotherapy-refractory disease JO - Gynecologic Oncology Research and Practice SP - 4 VL - 2 IS - 1 AB - Compared to other subtypes of epithelial ovarian cancer, clear cell carcinoma of the ovary bears an ominous reputation for chemotherapy resistance, increased relapse rate, and diminished survival. Among patients with distinct histopathologic subtypes, molecular analyses have identified a variety of known drivers of the malignant behavior, and depict a striking heterogeneity. SN - 2053-6844 UR - https://doi.org/10.1186/s40661-015-0013-2 DO - 10.1186/s40661-015-0013-2 ID - Castro2015 ER -