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Table 1 Low 185 passage whole genome sequencing

From: A long-term surviving patient with recurrent low-grade serous ovarian carcinoma treated with the MEK1/2 inhibitor, selumetinib

 

Tumor DNA

Blood DNA

 

Gene

Amino acid change

Mutant allele reads

Wild-type allele reads

Frequency of mutant allele

Mutant allele reads

Wild-type allele reads

Frequency of mutant allele

Functional impact

CCDC110

P209Q

7

9

44

0

8

0

Neutral

FAT1

Q2933P

6

6

50

0

6

0

Neutral

PCDHGA1

A443T

7

6

54

0

5

0

Neutral

USP45

K67E

6

6

50

0

5

0

Medium

RP1L1

Q1861P

5

7

42

0

9

0

Neutral

PLBD1

L25delL

7

7

50

0

9

0

Neutral

KRAS

G12V

8

11

42

0

9

0

Medium

KRT84

I206V

11

4

73

0

3

0

Neutral

ADAMTS17

N1094S

6

7

46

0

8

0

Neutral

ADAM33

M764T

7

9

44

0

4

0

Low