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Table 1 Oncologic outcomes after radical trachelectomy (where N > 100 reported)

From: Fertility-sparing management in cervical cancer: balancing oncologic outcomes with reproductive success

Study Eligible for fertility sparing (N) Stage (N) Histology (N) LVSI+ (N) Approach LN+ (N) Required adjuvant therapy (N) Successful fertility sparing (N) Primary recurrences (N) (mos) Dead of disease (N) (mos) Median follow up months (range)
Shepherd 2006 [108] 123 IA2 = 2
IB1 = 121
83 SCC
33 AC
3 AS
4 other
39 VRT 7 11 112 5 (15, 19, 21, 31, 84) 4 (26, 26, 32, 32) 45a (1–120)
Marchiole 2007 [109] 118 IA1 = 10
IA2 = 19
IB1 = 83
IIA = 6
90 SCC
25 AC/AS
3 rare
43 LAVRT 5 8 97 7 (7, 11, 18, 19, 20, 21, 93) 5 (21, 24, 26, 27. 41) 95 (31–234)
Plante 2011 [57] 140 IA1 = 7
IA2 = 30
IB1 = 97
IB2 = 3
IIA = 3
78 SCC
52 AC
10 AS
40 VRT 5 15 110 6 (−) 2 (−) 95 (4–225)
Helpman 2011 [35] 140 All IA-IB 74 AC 66 SCC 55 VRT 8 9 140 8 (−) 0 60 (−)
Wethington 2012 [110] 101 IA1 = 3
IA2 = 8
IB1 = 88
IB2 = 1
IIA = 1
40 SCC
6 AS
54 AC
1 clear cell
47 ART 19 20 70 4 (−) 0 32 (1–124)
Cao 2013 [51] 150 18 IA1
19 IA2
113 IB1
135 SCC
15 AC
8 VRT
ART
0 0 150 7 (−) 2 (−) 25 (6–91)
Mangler 2014 [111] 320¥ IA1 = 46
IA2 = 68
IB2 = 207
220 SCC
97 AC
5 AS
94 VRT 320 10 (mean 26.1 month, range 3–108) 5 (16, 19, 22, 29, 30) 48 (0–216)
Hauerberg 2015 [112] 120 CIS = 2
IA1 = 7
IA2 = 8
IB1 = 103
82 SCC
36 AC
2 AS
30 VRT 4 12 108 6 (−) 2 (−) 55.7 (5.5–147)
Vieira 2015 [113] 100 IA1 = 6
IA2 = 25
IB1 = 69
49 SCC
42 AC
7 AS
2 mixed
25 ART
RRT
LRT
2 9 83 0 0 51 (10–147)
Total N = 1312        N = 1190 N = 53 N = 20  
Crude rates (%)          Recurrence rate = 4.5 %# Mortality rate = 1.7 %#  
  1. Abbreviations: LVSI+ presence of lymphovascular space invasion, LN+ lymph node metastasis, SCC squamous cell carcinoma, AC adenocarcinoma, AS adenosquamous carcinoma, LAVRT laparoscopic-assisted vaginal radical trachelectomy, ART abdominal radical trachelectomy, VRT vaginal radical trachelectomy, RRT robotic radical trachelectomy
  2. aOnly mean follow up is reported
  3. #Crude recurrence and mortality rates among those who successfully had fertility preservation
  4. ¥In the original study, the sum of the stages and histologies are 321 and 322, respectively, but the reported N is 320