Fig. 1From: EZH2 inhibition in ARID1A mutated clear cell and endometrioid ovarian and endometrioid endometrial cancersNormal and ARID1A cellular pathways. ARID1A mutation disrupts the homeostatic mechanisms of the PI3K/AKT/mTOR pathway, resulting in cellular proliferation, angiogenesis and inhibited apoptosis (Fig. 1)Back to article page