Skip to main content

Table 3 Summary of toxicity profiles

From: A retrospective evaluation of activity of gemcitabine/platinum regimens in the treatment of recurrent ovarian cancer

Toxicity Profiles

Gemcitabine +Cisplatin

Gemcitabine + Carboplatin

Overall

N = 21

N = 27

Use of rescue antiemetics #(%)

6(29)

1(4)

Use of electrolyte replacement #(%)

5(24)

9(33)

Use of additional IV hydration

7(33)

8(30)

Change in renal function from baseline #(%)

4(19)

1(4)

Change in liver function from baseline #(%)

2(10)

6(22)

Mean dose reductions per patient [# + SD (Range)]

1.9 [+0.7(1–3)]

1.9 [+0.7(1–3)]

Mean treatment delays per patient[# + SD (Range)]

0.8 [+0.9(0–3)]

0.7 [+1(0–4)]

Mean rate of G-CSF administration per patient [# + SD (Range)]

2.9 [+3.3(0–9)]

4.2 [+3.2(0–9)]

Leukopenia, Grade 2 or greater #(%)

0

10(37)

Thrombocytopenia, Grade 2 or greater #(%)

0

2(7)

Neutropenia, Grade 2 or greater #(%)

4(19)

11(41)

  1. Abbreviation: SD Standard deviation