Toxicity Profiles | Gemcitabine +Cisplatin | Gemcitabine + Carboplatin |
---|---|---|
Overall | N = 21 | N = 27 |
Use of rescue antiemetics #(%) | 6(29) | 1(4) |
Use of electrolyte replacement #(%) | 5(24) | 9(33) |
Use of additional IV hydration | 7(33) | 8(30) |
Change in renal function from baseline #(%) | 4(19) | 1(4) |
Change in liver function from baseline #(%) | 2(10) | 6(22) |
Mean dose reductions per patient [# + SD (Range)] | 1.9 [+0.7(1–3)] | 1.9 [+0.7(1–3)] |
Mean treatment delays per patient[# + SD (Range)] | 0.8 [+0.9(0–3)] | 0.7 [+1(0–4)] |
Mean rate of G-CSF administration per patient [# + SD (Range)] | 2.9 [+3.3(0–9)] | 4.2 [+3.2(0–9)] |
Leukopenia, Grade 2 or greater #(%) | 0 | 10(37) |
Thrombocytopenia, Grade 2 or greater #(%) | 0 | 2(7) |
Neutropenia, Grade 2 or greater #(%) | 4(19) | 11(41) |