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Table 1 Effect of ML246 and cisplatin on SKOV3 xenograft growth and spread

From: A small molecule inhibitor of the perinucleolar compartment, ML246, attenuates growth and spread of ovarian cancer

Mouse ID

Treatment

Primary tumor volume(mm3)

Lesions outside of primary site (#)

Total # extraovarian lesions

201

cisplatin

195.7

 

0

203

cisplatin

738.2

 

0

204

cisplatin

70.3

 

0

205

cisplatin

287.3

 

0

207

cisplatin

208.9

back/subQ (1)

1

211

cisplatin

25.9

back/subQ (1)

1

214

cisplatin

51.2

 

0

217

cisplatin

NR

mouse died

 

229

cisplatin

NT

 

0

234

cisplatin

93.3

back/subQ (1)

1

206

vehicle

small

back/subQ (1)

1

208

vehicle

NR

mouse died

 

209

vehicle

172.6

back/subQ (1)

1

210

vehicle

118.3

 

0

212

vehicle

11.7

pelvis (1); back/subQ (1)

2

221

vehicle

3.4

 

0

222

vehicle

35.9

cecum (1);

1

224

vehicle

323.8

diaphram (2); pelvis (1); bowel (1); back/subQ (1); mesentery (1)

6

225

vehicle

184.4

back/subQ (1)

1

223

vehicle

212.0

 

0

230

vehicle

234.0

bowel (2)

2

233

vehicle

small

pelvis (1)

1

202

ML246

NR

mouse died

 

213

ML246

14.3

 

0

215

ML246

NT

 

0

216

ML246

140.7

back/subQ (1)

1

218

ML246

NR

mouse died

 

219

ML246

114.6

back/subQ (1)

1

220

ML246

917.4

 

0

226

ML246

NT

back/subQ (2)

2

227

ML246

NR

mouse died

 

228

ML246

NT

 

0

231

ML246

NT

 

0

232

ML246

213.3

 

0

  1. NT No tumor, SubQ Subcutaneous, NR Not recorded