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Gynecologic Oncology Research and Practice

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  1. Content type: Research

    Our objective was to determine if previously reported overall survival (OS) and progression-free survival (PFS) rates are maintained long term following multimodal therapy for advanced and recurrent endometria...

    Authors: Michelle Glasgow, Rachel Isaksson Vogel, Jennifer Burgart, Peter Argenta, Kathryn Dusenbery and Melissa A. Geller

    Citation: Gynecologic Oncology Research and Practice 2016 3:6

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  2. Content type: Case report

    Selumetinib is a potent, selective, orally available, and non-ATP competitive small molecule inhibitor of mitogen-activated protein kinase kinase 1/2 (MEK1/2) that has demonstrated single agent activity in a n...

    Authors: Munetaka Takekuma, Kwong K. Wong and Robert L. Coleman

    Citation: Gynecologic Oncology Research and Practice 2016 3:5

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  3. Content type: Research

    After platinum and taxane chemotherapy, with or without bevacizumab, active regimens for advanced or recurrent cervical cancer are lacking. Our objective was to review a single institution experience in treati...

    Authors: Lindsey E. Minion, Dana M. Chase, John H. Farley, Lyndsay J. Willmott and Bradley J. Monk

    Citation: Gynecologic Oncology Research and Practice 2016 3:4

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  4. Content type: Review

    Poly(ADP-ribose) polymerase (PARP), which was first described over 50 years ago by Mandel, are a family of protein enzymes involved in DNA damage response and works by recognizing the single-strand DNA break (...

    Authors: Robert S. Meehan and Alice P. Chen

    Citation: Gynecologic Oncology Research and Practice 2016 3:3

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  5. Content type: Research

    Many women who develop endometrial cancer (EC) or endometrial hyperplasia with atypia are obese and therefore at high risk of surgical complications. Recently clinical trials have been initiated offering non-s...

    Authors: Andreas Obermair, Donal J. Brennan, Eva Baxter, Jane E. Armes, Val Gebski and Monika Janda

    Citation: Gynecologic Oncology Research and Practice 2016 3:1

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  6. Content type: Case report

    Radiation induced Lumbosacral plexophaty (RILP) is a rare but severe complication that has a considerable impact on quality of life. Its occurrence is rare but increasing with improved long-term cancer surviva...

    Authors: Imane Bourhafour, Meriem Benoulaid, Hanane El Kacemi, Sanae El Majjaoui, Tayeb Kebdani and Noureddine Benjaafar

    Citation: Gynecologic Oncology Research and Practice 2015 2:12

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  7. Content type: Review

    Endometrial cancer is the only gynecologic malignancy with a rising incidence and mortality. While cure is routinely achieved with surgery alone or in combination with adjuvant pelvic radiotherapy when disease...

    Authors: Teresa C. Longoria and Ramez N. Eskander

    Citation: Gynecologic Oncology Research and Practice 2015 2:11

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    The Erratum to this article has been published in Gynecologic Oncology Research and Practice 2016 3:2

  8. Content type: Research

    Early-stage vaginal and vulvar cancer can be cured. But outcomes of patients with metastatic disease are poor. Thus, new therapeutic strategies are urgently required.

    Authors: Siqing Fu, Naiyi Shi, Jennifer Wheler, Aung Naing, Filip Janku, Sarina Piha-Paul, Jing Gong, David Hong, Apostolia Tsimberidou, Ralph Zinner, Vivek Subbiah, Ming-Mo Hou, Pedro Ramirez, Lois Ramondetta, Karen Lu and Funda Meric-Bernstam

    Citation: Gynecologic Oncology Research and Practice 2015 2:10

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  9. Content type: Research

    The incidence of molar pregnancy has demonstrated marked geographic and ethnic differences. The reported data in Nepal is inconsistent with minimal published literature. Thus, we designed a study to determine ...

    Authors: Nimisha Agrawal, Reshu Agrawal Sagtani, Shyam Sundar Budhathoki and Hanoon P. Pokharel

    Citation: Gynecologic Oncology Research and Practice 2015 2:9

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  10. Content type: Review

    Despite the introduction of screening and, latterly, vaccination programs in the developed world, globally cervical cancer remains a significant health problem. For those diagnosed with advanced or recurrent d...

    Authors: Victor Rodriguez-Freixinos and Helen J. Mackay

    Citation: Gynecologic Oncology Research and Practice 2015 2:8

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  11. Content type: Case report

    Cervical cancer (CC) is one of the most widespread gynecological malignancies in women worldwide. Treatment strategies and screening modalities have largely evolved these past years resulting in an improvement...

    Authors: J. Khalil, S. Bellefqih, N. Sahli, M. Afif, H. Elkacemi, S. Elmajjaoui, T. Kebdani and N. Benjaafar

    Citation: Gynecologic Oncology Research and Practice 2015 2:7

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  12. Content type: Research

    In Ethiopia, cervical cancer (CC) ranks the 2nd most frequent cancer and the country had 27.19 million women at risk of developing the disease though only 0.6 % women age 18-69 years was screened every 3 years...

    Authors: Netsanet Belete, Yosief Tsige and Habtamu Mellie

    Citation: Gynecologic Oncology Research and Practice 2015 2:6

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  13. Content type: Review

    Recently accumulated evidence has strongly indicated that the fallopian tube is the site of origin for the majority of high-grade serous ovarian or peritoneal carcinomas. As a result, recommendations have been...

    Authors: Gillian E. Hanley, Jessica N. McAlpine, Janice S. Kwon and Gillian Mitchell

    Citation: Gynecologic Oncology Research and Practice 2015 2:5

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  14. Content type: Case report

    Compared to other subtypes of epithelial ovarian cancer, clear cell carcinoma of the ovary bears an ominous reputation for chemotherapy resistance, increased relapse rate, and diminished survival. Among patien...

    Authors: Michael P. Castro, Bradford P. Whitcomb, Deborah A. Zajchowski and Robert L. Coleman

    Citation: Gynecologic Oncology Research and Practice 2015 2:4

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  15. Content type: Research

    Cancer of uterine cervix is the second most common cause of cancer related deaths among women. The aim of this study is to report the experience of Military Hospital Mohamed V in the management of cervical can...

    Authors: Mohammed Elmarjany, Abdelhak Maghous, Rachid Razine, Elamin Marnouche, Khalid Andaloussi, Amine Bazine, Issam Lalya, Noha Zaghba, Khalid Hadadi, Hassan Sifat, Baba Habib, Jaouad Kouach and Hamid Mansouri

    Citation: Gynecologic Oncology Research and Practice 2015 2:2

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  16. Content type: Case report

    Clear cell adenocarcinoma of the cervix is a rare tumor of the lower genital tract. It has been described in young women with a history of intra uterine exposure to diethylstilbestrol. This tumor is characteri...

    Authors: Ablavi Adani-Ifè, Emma Goldschmidt, Pasquale Innominato, Ayhan Ulusakarya, Hassan Errihani, Philippe Bertheau and Jean François Morère

    Citation: Gynecologic Oncology Research and Practice 2015 2:3

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  17. Content type: Review

    Traditionally, epithelial ovarian, tubal, and peritoneal cancers have been viewed as separate entities with disparate origins, pathogenesis, clinical features, and outcomes. Additionally, previous classificati...

    Authors: Lauren Patterson Cobb, Stephanie Gaillard, Yihong Wang, Ie-Ming Shih and Angeles Alvarez Secord

    Citation: Gynecologic Oncology Research and Practice 2015 2:1

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  18. Content type: Case report

    Pelvic actinomycosis comprises a rare, subacute to chronic bacterial infection characterised by suppurative and granulomatous inflammation. Diagnosis is difficult as it may simulate pelvic malignancies. Labora...

    Authors: Alex Laios, Iryna Terekh, Hooman Soleymani Majd, Pubudu Pathiraja, Sanjiv Manek and Krishnayan Haldar

    Citation: Gynecologic Oncology Research and Practice 2014 1:5

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  19. Content type: Research

    While most gynecologic cancers respond to first-line cytotoxic chemotherapy, treatment of recurrent disease is frequently associated with acquired drug resistance. In order to find an in vitro surrogate of thi...

    Authors: Heather J Dalton, James Fiorica, Candace K McClure, Rodney P Rocconi, Fernando O Recio, John L Levocchio, Matthew O Burrell and Bradley J Monk

    Citation: Gynecologic Oncology Research and Practice 2014 1:7

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  20. Content type: Case report

    Metastatic carcinoma to the uterine cervix from colorectal cancer, through haematogenous or lymphatic spread, is extremely rare. We report the case of a 59 year old woman in whom cervical metastasis was diagno...

    Authors: Soufiane Berhili, Basma El Khannoussi, Selma Kadiri, Imane Mezouri, Amine Bazine, Asmae Touil, Imane El Khiyat, Tayeb Kebdani and Noureddine Benjaafar

    Citation: Gynecologic Oncology Research and Practice 2014 1:6

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  21. Content type: Research

    To explore the activity of dasatinib alone and in combination with gemcitabine and docetaxel in uterine leiomyosarcoma (uLMS) cell lines, and determine if dasatinib inhibits the SRC pathway.

    Authors: Micael Lopez-Acevedo, Lisa Grace, Deanna Teoh, Regina Whitaker, David J Adams, Jingquan Jia, Andrew B Nixon and Angeles Alvarez Secord

    Citation: Gynecologic Oncology Research and Practice 2014 1:2

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  22. Content type: Review

    Drug discovery in the ovarian cancer arena continues to launch important new clinical trials. Many biologic agents are being studied in phase II and phase III clinical trials for recurrent disease. These agent...

    Authors: Steven J Gibson, Krishnansu S Tewari, Bradley J Monk and Dana M Chase

    Citation: Gynecologic Oncology Research and Practice 2014 1:3

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